People
Dr. Pierre-Gilles Henry
Dr. Henry is an Assistant Professor of Radiology in the University's Center for Magnetic Resonance Research. He is interested in exploring various aspects of cellular metabolism in the brain via magnetic resonance spectroscopy. To this end, he guides group research in rat and mouse models utilizing both proton and C13 spectra. Projects have encompassed cutting edge MR methods development and animal models of disease including schizophrenia.
Curriculum Vitae for PGH
Dr. Alexander Shestov
Dr. Shestov is specialized in mathematical modeling of complex biological systems. His current work focuses on metabolic modeling of 13C NMR spectroscopy data to study brain metabolism and neurotransmission. He has been using Monte-Carlo simulations to investigate the reliability of two-compartment neuronal-glial models to measure brain energy metabolism and neurotransmission. He also developed new metabolic models (isotopomer models) to take advantage of the unique information available in 13C spectra. Dr. Shestov's research is shedding new light on the exquisite mechanisms that regulate brain metabolism and neurotransmission at the level of cellular cooperation between neurons and astrocytes.
Dr. Dinesh Deelchand
Dr. Dinesh Deelchand is a Research Associate and holds a Ph.D.in Physics from Nottingham, UK. His works focuses on developing and validating new approaches to study brain metabolism and neurotransmission using 13C and 1H NMR spectroscopy (MRS). He has been using novel substrates such as 13C-acetate to investigate compartmentalized brain metabolism at the level of cellular cooperation between neurons and astrocytes. He is also involved in the development of hyperpolarized 13C techniques which have the potential to dramatically improve the sensitivity of 13C MRS measurement in vivo. In addition to this 13C MRS effort, his 1H MRS studies focus on further improving detection pulses sequences for 1H MRS at high-field as well as quantification of 1H MR spectra using simulated basis sets. In particular, he is developing 1H NMR spectroscopy in human brain at 9.4 Tesla, the highest magnetic field currently available for human studies, with only 3 systems installed worldwide.
Dr. Isabelle Iltis
Dr. Iltis graduated from the Université de la Méditerranée, Aix-Marseille II in 2005. She did her PhD thesis in the Centre de Résonance Magnétique Biologique et Médicale (CRMBM) in Marseille, where she studied myocardial blood flow in the rat in vivo, using non-invasive ASL methods . She came to Minnesota in April 2005 and is since then a post-doc at the CMRR. She has been studying mainly brain metabolism in human and rodent models using 1H- and 13C-MRS methods developed at CMRR. She is now getting involved in applications of hyperpolarized 13C in vivo.
Manda Vollmers
Ms. Vollmers is the surgical technician for the Henry group. She is involved in the preparation of animals for MRS experiments, and monitors them during anaesthesia. She is also responsible for maintaining lab equipment and supplies, processing tissue for analysis, and keeping the rest of the lab in line.
Dee Koski
Ms. Koski was formerly the primary surgical and anesthesia technician for the group, and now provides her services on a part-time consultant basis. She has many years' experience in various aspects of lab animal research, as well as in the day-to-day aspects of running a research lab. She is currently pursuing her D.V.M. here in the University's College of Veterinary Medicine.
Chris Nelson
Mr. Nelson is a former surgical technician for the group. Questions, comments, and complaints about this website may be addressed to him at nelso806 - at - umn - dot - edu.